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Case Report
Nephrogenic adenoma in a female urethral diverticulum: Clinical presentation and surgical management
1 Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
2 Medical Student, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
3 Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
4 Department of Urology, 200 Hawkins Drive, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Address correspondence to:
Leanne Brechtel
200 Hawkins Ave, Iowa City, IA 52242,
USA
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Article ID: 100068Z15LB2026
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How to cite this article
Brechtel L, Venkatesh V, Christensen N, Stauffer S, Vollstedt A. Nephrogenic adenoma in a female urethral diverticulum: Clinical presentation and surgical management. J Case Rep Images Urol 2026;11(2):7–11.ABSTRACT
Introduction: Nephrogenic adenoma is a benign lesion of the urinary tract that is rarely found within a urethral diverticulum. The nonspecific symptoms of urethral diverticula can often lead to delayed or missed diagnosis, complicating management.
Case Report: We present the case of a woman who presented with vaginal discomfort and was ultimately found to have a periurethral mass. Pelvic magnetic resonance imaging (MRI) confirmed the presence of a periurethral mass. Definitive surgical excision and histopathological analysis confirmed the presence of nephrogenic adenoma within the urethral diverticulum. Postoperatively, the patient did well with near resolution of her symptoms.
Conclusion: This case highlights the importance of a broad differential diagnosis, the utility of advanced imaging, and relying on histopathology to distinguish between benign and malignant lesions. For nephrogenic adenoma, surgical excision remains the optimal treatment, often offering excellent outcomes.
Keywords: Histopathology, Nephrogenic adenoma, Surgical technique, Urethral diverticulum, Vaginal surgery
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Author Contributions
Leanne Brechtel - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Veena Venkatesh - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Nathanael Christensen - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Stephanie Stauffer - Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Annah Vollstedt - Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2026 Leanne Brechtel et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
