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Case Report
Ipsilateral synchronous renal cell carcinoma and transitional cell carcinoma of the pelvicalyceal system
1 Department of Urology, University of Balamand, Saint George Hospital University Medical Hospital, Beirut, Lebanon
2 Department of Internal Medicine, University of Balamand, Saint George Hospital University Medical Hospital, Beirut, Lebanon
3 American University of Beirut, Faculty of Arts and Sciences, Beirut, Lebanon
4 Department of Medical Imaging, University of Balamand, Saint George Hospital University Medical Hospital, Beirut, Lebanon
Address correspondence to:
Teddy Jabbour
MD, Department of Urology, University of Balamand, Saint George Hospital University Medical Hospital, Beirut,
Lebanon
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Article ID: 100021Z15TJ2021
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Jabbour T, Akl B, Haydar A, Jabbour C, Haddad L, Jabbour M. Ipsilateral synchronous renal cell carcinoma and transitional cell carcinoma of the pelvicalyceal system. J Case Rep Images Urol 2021;6:100021Z15TJ2021.ABSTRACT
Introduction: Ipsilateral synchronous renal cell carcinoma and transitional cell carcinoma of the 8 pelvicalyceal system are rare occurrences with data from 1977 showing a 0.14% prevalence with a 24% association with smoking. 90% of patients present with hematuria. Serum hepcidin levels and serum GDF-15 levels are typically elevated in patients with upper urinary tract transitional cell carcinoma (TCC) and renal cell carcinoma (RCC). Possible associations with genomic mutations such as in Birt-Hogg Dubé syndrome, due to a mutation in the folliculin (FLCN) gene, and in Lynch syndrome, due to a mutation in four different mismatch repair genes. The current recommended treatment is nephroureterectomy. Due to the rarity of this disease, prospective studies regarding the usage of neoadjuvant chemotherapy treatment have been limited.
Case Report: We present the rare case of a 72-year-old male found to have Ipsilateral synchronous renal cell carcinoma and transitional cell carcinoma of the pelvicalyceal system that underwent a laparoscopic nephroureterectomy that showed typical findings of a Stage pT1a and WHO/ISUP grade 2 RCC and a Stage pTa TCC in the renal pelvis, with a stage pTa and Grade I in the bladder.
Conclusion: Further follow-up reports must be provided on this rare entity with long-term follow-up to provide further recommendation for the treatment of synchronous ipsilateral TCC and RCC.
Keywords: Ipsilateral, Renal cell carcinoma, Synchronous, Transitional cell carcinoma
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Author Contributions
Teddy Jabbour - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Bernard Akl - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Asad Haydar - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Christelle Jabbour - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Laura Haddad - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Michel Jabbour - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Teddy Jabbour et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
