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Case Report
Pulmonary alveolar microlithiasis with calcifications in the seminal vesicles and prostate causing infertility: A case report
1 Pneumo-phthisiology Department, Moulay Youssef Hospital, Faculty of Medicine and Pharmacy of Rabat, Morocco
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Nezha Reguig
Pneumo-phthisiology Department, Moulay Youssef Hospital, Faculty of Medicine and Pharmacy of Rabat,
Morocco
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Article ID: 100045Z15NR2024
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Reguig N, Messaoudi MA, Omari W, Aharmim M, Soualhi M, Zahraoui R. Pulmonary alveolar microlithiasis with calcifications in the seminal vesicles and prostate causing infertility: A case report. J Case Rep Images Urol 2024;9(2):1–4.ABSTRACT
Introduction: Pulmonary alveolar microlithiasis (PAM) is a rare hereditary disease caused by the mutation of the SLC34A2 gene, characterized by the deposition of calcium phosphate microliths throughout the alveolar spaces. Calcifications have also been reported in other organs such as the genitalia of male patients and can be associated with infertility cases. Our case report is the first Moroccan case reported in the literature of a male with PAM and infertility.
Case Report: We present a case of a 47-year-old male patient (Moroccan, North African) presented with complaints of persistent grade I dyspnea for the last six years. He also claimed primary infertility of 20 years since marriage, PAM was diagnosed based on the typical appearance of the chest and pelvic high resolution computed tomography (HRCT). The infertility was due to distal obstruction of the seminal tract by small calcifications similar to pulmonary microliths. Low dose inhaled corticosteroids/long-acting beta2-agonists (ICS-LABA) was started as a treatment of symptoms with good control of symptoms.
Conclusion: Pulmonary alveolar microlithiasis is a rare autosomal recessive disorder not easily described because of its rarity worldwide, its clinical course, and its evolution. Its association with infertility may be more common than is currently known, suggests the need to make a particularly close examination of the chest X-ray in some cases of male infertility.
Keywords: Hereditary disease, Infertility, Oligoasthenospermia, Prostate, Pulmonary alveolar microlithiasis, Seminal vesicles
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Author Contributions
Nezha Reguig - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mohamed Anouar Messaoudi - Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Wafae Omari - Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mohammed Aharmim - Conception of the work, Design of the work, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mouna Soualhi - Conception of the work, Design of the work, Acquisition of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Rachida Zahraoui - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Nezha Reguig et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
